Potentiometric Sensing of Nonsteroidal Painkillers by Acyclic Squaramide Ionophores.

ABSTRACT: We report here a small library of a new type of acyclic squaramide receptors (L1-L5) as selective ionophores for the detection of ketoprofen and naproxen anions (KF^- and NS^-, respectively) in aqueous media. ¹H NMR binding studies show a high affinity of these squaramide receptors toward KF^- and NS^-, suggesting the formation of H-bonds between the two guests and the receptors through indole and -NH groups. Compounds L1-L5 have been tested as ionophores for the detection of KF^- and NS^- inside solvent PVC-based polymeric membranes. The optimal membrane compositions were established through the careful variation of the ligand/tridodecylmethylammonium chloride (TDMACl) anion-exchanger ratio.

SUBMITTER: Picci G 

PROVIDER: S-EPMC10463271 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature