Analysis on EZH2: mechanism identification of related CeRNA and its immunoassay in hepatocellular carcinoma.

ABSTRACT:

Objective

To screen the possible potential signaling pathways related to enhancer of zeste homolog 2 (EZH2) based on ceRNA mechanism, and to analyze the correlation between E2H2 and depths of various immune cell infiltration depths. The relationship between different immune checkpoints were also analyzed.

Methods

First, the expression of EZH2 in pan-cancer (18 malignancies) was analyzed with the TCGA database. Hepatocellular carcinoma (HCC) tissues of 374 cases and normal tissues of 50 cases were analyzed in terms of the differential expression, overall survival (OS) and progression-free-survival (PFS). Then, we conducted GO and KEGG enrichment analysis on target gene. We also analyzed mRNA-miRNA and MicroRNA (miRNA)- long non-coding RNA (lncRNA) correlation with starbase da

SUBMITTER: Zhao H 

PROVIDER: S-EPMC10463302 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature