SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) is expected to soon surpass colorectal cancer as a leading cause of cancer mortality in both males and females in the US, only lagging behind lung cancer. The lethality of PDAC is driven by late diagnosis and inefficient therapies. The complex biology of PDAC involves various cellular components, including exosomes that carry molecular information between cells. Thus, recipient cells can be reprogrammed, impacting tumorigenesis. Rab27a is a GTPase responsible for the last step of exosomes biogenesis. Hence, dissecting the mechanisms that regulate the expression of Rab27a and that control exosomes biogenesis can provide fundamental insights into the molecular underpinnings regulating PDAC progression.

Methods

To assess the me

SUBMITTER: Bastos N 

PROVIDER: S-EPMC10463307 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature