Circulating insulin-like growth factor-1 and brain health: Evidence from 369,711 participants in the UK Biobank.

ABSTRACT:

Background

The effects of insulin-like growth factor-1 (IGF-1) deficiency on cognitive decline have been consistently reported in animal studies, but the relationship between IGF-1 and human brain health remains controversial. Our study aimed to investigate the associations of serum IGF-1 concentrations with some brain-related disorders and neuroimaging features.

Methods

This prospective study included 369,711 participants (55.8 ± 8.1 years) from the UK biobank who had serum IGF-1 measured and were free from brain-related disorders of interest - dementia, stroke, and Parkinson's disease (PD) - at enrollment (2006-2010). Restricted cubic splines and Cox proportional hazards models were used to detect the associations between IGF-1 concentrations and brain-related diseases. In

SUBMITTER: Cao Z 

PROVIDER: S-EPMC10463341 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature