Clinical manifestation for immunoglobulin A deficiency: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Immunoglobulin A deficiency (IgAD) is a common disease with an unknown genetic defect, characterized by the decreased or absent IgA with other isotypes normal, normal subclasses, and specific antibodies. Patients with this disorder represent a spectrum of clinical manifestations including infections, autoimmune disorders, malignancy, and allergic diseases. The current study aimed to evaluate their prevalence and categorized them.

Methods

We searched PubMed, Web of Science, and Scopus databases to find eligible studies from the earliest available date to January 2022 with standard keywords. Pooled estimates of clinical manifestations prevalence and the corresponding 95% confidence intervals were calculated using random-effects models.

Results

The most preval

SUBMITTER: Vosughimotlagh A 

PROVIDER: S-EPMC10463351 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature