Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer.

ABSTRACT:

Introduction

Ovarian cancer (OC) is one of the most common gynecologic malignant cancers with the current survival rate remaining low. TRPM2 has been reported as a survival predictor in various cancers but not in OC. The aim of this study is to explore the role and its underlying mechanism of TRPM2 in OC.

Methods

The transcriptome data and clinical data were obtained from TCGA, GTEx, and GEO (GSE17260). DriverDBv3 and PrognoScan were used to analyze survival correlations. GSEA analysis was performed to uncover the underlying mechanism. The correlations between TRPM2 and immune score, immune cell infiltration were analyzed by TIMER2.0.

Results

TRPM2 was highly expressed in OC and high TRPM2 expression was related to the poor prognosis based on the Kaplan-Meier curves,

SUBMITTER: Huang W 

PROVIDER: S-EPMC10463424 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature