Respiratory and Cardiometabolic Comorbidities and Stages I to III NSCLC Survival: A Pooled Analysis From the International Lung Cancer Consortium.

ABSTRACT:

Introduction

We explored the association of respiratory and cardiometabolic comorbidities with NSCLC overall survival (OS) and lung cancer-specific survival (LCSS), by stage, in a large, multicontinent NSCLC pooled data set.

Methods

On the basis of patients pooled from 11 International Lung Cancer Consortium studies with available respiratory and cardiometabolic comorbidity data, adjusted hazard ratios (aHRs) were estimated using Cox models for OS. LCSS was evaluated using competing risk Grey and Fine models and cumulative incidence functions. Logistic regression (adjusted OR [aOR]) was applied to assess factors associated with surgical resection.

Results

OS analyses used patients with NSCLC with respiratory health or cardiometabolic health data (N = 16,354); a subset

SUBMITTER: Garcia-Pardo M 

PROVIDER: S-EPMC10463560 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature