Genome-wide analysis of circRNA regulation during spleen development of Chinese indigenous breed Meishan pigs.

ABSTRACT:

Background

Numerous circular RNAs (circRNAs) have been recently identified in porcine tissues and cell types. Nevertheless, their significance in porcine spleen development is yet unelucidated. Herein, we reported an extensive overlook of circRNA expression profile during spleen development in Meishan pigs.

Results

Overall, 39,641 circRNAs were identified from 6,914 host genes. Among them, many circRNAs are up- or down-regulated at different time points of pig spleen development. Using WGCNA analysis, we revealed two essential modules for protein-coding genes and circRNAs. Subsequent correlation analysis revealed 67 circRNAs/co-expressed genes that participated in immnue-associated networks. Furthermore, a competing endogenous RNA (ceRNA) network analysis of circRNAs reveale

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10463621 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature