Global comparative transcriptomes uncover novel and population-specific gene expression in esophageal squamous cell carcinoma.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) has a poor prognosis and is one of the deadliest gastrointestinal malignancies. Despite numerous transcriptomics studies to understand its molecular basis, the impact of population-specific differences on this disease remains unexplored.

Aims

This study aimed to investigate the population-specific differences in gene expression patterns among ESCC samples obtained from six distinct global populations, identify differentially expressed genes (DEGs) and their associated pathways, and identify potential biomarkers for ESCC diagnosis and prognosis. In addition, this study deciphers population specific microbial and chemical risk factors in ESCC.

Methods

We compared the gene expression patterns of ESCC samples from six d

SUBMITTER: Alotaibi A 

PROVIDER: S-EPMC10463703 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature