Multiparametric chemical exchange saturation transfer MRI detects metabolic changes in breast cancer following immunotherapy.

ABSTRACT:

Background

With metabolic alterations of the tumor microenvironment (TME) contributing to cancer progression, metastatic spread and response to targeted therapies, non-invasive and repetitive imaging of tumor metabolism is of major importance. The purpose of this study was to investigate whether multiparametric chemical exchange saturation transfer magnetic resonance imaging (CEST-MRI) allows to detect differences in the metabolic profiles of the TME in murine breast cancer models with divergent degrees of malignancy and to assess their response to immunotherapy.

Methods

Tumor characteristics of highly malignant 4T1 and low malignant 67NR murine breast cancer models were investigated, and their changes during tumor progression and immune checkpoint inhibitor (ICI) treatment

SUBMITTER: Hoffmann E 

PROVIDER: S-EPMC10463706 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature