The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance.

ABSTRACT: RNA-binding proteins have increasingly been identified as important regulators of gene expression given their ability to bind distinct RNA sequences and regulate their fate. Mounting evidence suggests that RNA-binding proteins are involved in the onset and progression of multiple malignancies, prompting increasing interest in their potential for therapeutic intervention.The Musashi RNA binding proteins Musashi-1 and Musashi-2 were initially identified as developmental factors of the nervous system but have more recently been found to be ubiquitously expressed in physiological tissues and may be involved in pathological cell behavior. Both proteins are increasingly investigated in cancers given dysregulation in multiple tumor entities, including in female malignancies. Recent data suggest t

SUBMITTER: Sicking M 

PROVIDER: S-EPMC10463710 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature