Subcutaneous adipose tissue alteration in aging process associated with thyroid hormone signaling.

ABSTRACT:

Background

Functional changes in subcutaneous adipose tissue (SAT) occur earlier in the aging process and play an important role in the occurrence and development of age-related metabolic diseases. The mechanism of this phenomenon is still unclear, and the change in adipose tissue with age is poorly understood.

Methods

We used transcriptome sequencing (RNA seq) to screen differentially expressed genes at the mRNA level, and analyzed the functional characteristics of the differential genes through GO and KEGG analysis in human SAT of all ages. In order to clarify the specific mechanism of the functional change, we analyzed the chromatin accessibility in the promoter region in the same SAT used in the RNA seq by the assay for transposase-accessible chromatin with high throughp

SUBMITTER: Zhang WN 

PROVIDER: S-EPMC10463827 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature