Opening of Cx43-formed hemichannels mediates the Ca²⁺ signaling associated with endothelial cell migration.

ABSTRACT: Endothelial cell migration is a key process in angiogenesis. Progress of endothelial cell migration is orchestrated by coordinated generation of Ca²⁺ signals through a mechanism organized in caveolar microdomains. Connexins (Cx) play a central role in coordination of endothelial cell function, directly by cell-to-cell communication via gap junction and, indirectly, by the release of autocrine/paracrine signals through Cx-formed hemichannels. However, Cx hemichannels are also permeable to Ca²⁺ and Cx43 can be associated with caveolin-1, a structural protein of caveolae. We proposed that endothelial cell migration relies on Cx43 hemichannel opening. Here we show a novel mechanism of Ca²⁺ signaling in endothelial cell migration. The Ca²⁺ signaling t

SUBMITTER: Espinoza H 

PROVIDER: S-EPMC10463847 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature