NHS-POx-loaded patch versus fibrin sealant patch in a porcine robotic liver bleeding model.

ABSTRACT:

Background

The management of bleeding is paramount to any surgical procedure. With the increased use of less invasive laparoscopic and robotic methods, achieving hemostasis can be challenging since the surgeons cannot manually apply hemostatic agents directly onto bleeding tissue. In this study, we assessed the use of a pliable hemostatic sealant patch comprising fibrous gelatin carrier impregnated with poly(2-oxazoline) (NHS-POx) for hemostasis in robotic liver resection in a porcine bleeding model.

Methods

The NHS-POx-loaded patch (GATT-Patch), was first evaluated in a Feasibility Study to treat surgical bleeding in 10 lesions, followed by a Comparative Study in which the NHS-POx patch was compared to a standard-of-care fibrin sealant patch (TachoSil), in 36 lesions (super

SUBMITTER: D'Hondt M 

PROVIDER: S-EPMC10463878 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature