Subclinical cardiac dysfunction may impact on fluid and vasopressor administration during early resuscitation of septic shock.

ABSTRACT:

Background

According to the Surviving Sepsis Campaign (SSC) fluids and vasopressors are the mainstays of early resuscitation of septic shock while inotropes are indicated in case of tissue hypoperfusion refractory to fluids and vasopressors, suggesting severe cardiac dysfunction. However, septic cardiac disfunction encompasses a large spectrum of severities and may remain "subclinical" during early resuscitation. We hypothesized that "subclinical" cardiac dysfunction may nevertheless influence fluid and vasopressor administration during early resuscitation. We retrospectively reviewed prospectically collected data on fluids and vasoconstrictors administered outside the ICU in patients with septic shock resuscitated according to the SSC guidelines that had reached hemodynamic stabil

SUBMITTER: Murgolo F 

PROVIDER: S-EPMC10463881 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature