High-intensity walking in midlife is associated with improved memory in physically capable older adults.

ABSTRACT:

Background

Little is known about the associations of midlife- and late life-initiated walking with Alzheimer's disease (AD)-related cognitive decline in humans. We aimed to investigate whether high-intensity, prolonged, midlife-initiated walking is associated with changes in AD-related cognitive decline in physically capable older adults.

Methods

We studied 188 physically capable participants aged 65-90 years without dementia who underwent comprehensive clinical assessment, including of their walking modality (i.e., intensity, duration, midlife- or late life-onset), memory- or non-memory and total cognitive performance, and blood or nutritional biomarkers.

Results

The walking group showed better episodic memory (B = 2.852, SE = 1.214, β = 0.144, p = 0.020), but not no

SUBMITTER: Choe YM 

PROVIDER: S-EPMC10463890 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature