Metabolic characteristics and pathogenesis of precocious puberty in girls: the role of perfluorinated compounds.

ABSTRACT:

Background

Precocious puberty (PP) in girls is traditionally defined as the onset of breast development before the age of 8 years. The specific biomarkers of premature thelarche (PT) and central precocious puberty (CPP) girls are uncertain, and little is known about their metabolic characteristics driven by perfluorinated compounds (PFCs) and clinical phenotype. This study aimed to screen specific biomarkers of PT and CPP and elucidate their underlying pathogenesis. The relationships of clinical phenotype-serum PFCs-metabolic characteristics were also explored to reveal the relationship between PFCs and the occurrence and development of PT and CPP.

Methods

Nuclear magnetic resonance (NMR)-based cross-metabolomics strategy was performed on serum from 146 PP (including 30 CPP,

SUBMITTER: Wu J 

PROVIDER: S-EPMC10463894 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature