The potential of cystatin C as a predictive biomarker in pulmonary hypertension.

ABSTRACT:

Background

Cystatin C is a novel biomarker to identify renal dysfunction and cardiovascular risk.

Objective

The aim of this study was to investigate the role of cystatin C in non-invasive risk prediction in a large cohort of patients with pre-capillary pulmonary hypertension (PH).

Method

We retrospectively analyzed pre-capillary PH patients with available cystatin C and hemodynamic data derived from right heart catheterization.

Results

A total of 398 consecutive patients with confirmed pre-capillary PH were recruited from Fuwai Hospital between November 2020 and November 2021. Over a median duration of 282 days, 72 (18.1%) of these patients experienced clinical worsening. Cystatin C levels significantly correlated with cardiac index (r = -0.286, P < 0.001), mix

SUBMITTER: Duan A 

PROVIDER: S-EPMC10463899 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature