A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers.

ABSTRACT: The biological barriers have seriously restricted the efficacious responses of oral delivery system in diseases treatment. Utilizing a carrier based on the single construction means is hard to overcome these obstacles simultaneously because the complex gastrointestinal tract environment requires carrier to have different or even contradictory properties. Interestingly, spore capsid (SC) integrates many unique biological characteristics, such as high resistance, good stability etc. This fact offers a boundless source of inspiration for the construction of multi-functional oral nanoplatform based on SC without further modification. Herein, we develop a type of biomimetic spore nanoplatform (SC@DS NPs) to successively overcome oral biological barriers. Firstly, doxorubicin (DOX) and sorafenib

SUBMITTER: Song Q 

PROVIDER: S-EPMC10463901 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature