Cortical superficial siderosis is associated with reactive astrogliosis in cerebral amyloid angiopathy.

ABSTRACT:

Background

Cortical superficial siderosis (cSS) has recently emerged as one of the most important predictors of symptomatic intracerebral hemorrhage and is a risk factor for post-stroke dementia in cerebral amyloid angiopathy (CAA). However, it remains unknown whether cSS is just a marker of severe CAA pathology or may itself contribute to intracerebral hemorrhage risk and cognitive decline. cSS is a chronic manifestation of convexal subarachnoid hemorrhage and is neuropathologically characterized by iron deposits in the superficial cortical layers. We hypothesized that these iron deposits lead to local neuroinflammation, a potentially contributory pathway towards secondary tissue injury.

Methods

Accordingly, we assessed the distribution of inflammatory markers in relation t

SUBMITTER: Auger CA 

PROVIDER: S-EPMC10463916 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature