Tranexamic acid can reduce blood loss in adolescent scoliosis surgery: a systematic review and meta-analysis

ABSTRACT:

Background

Tranexamic acid (TXA) has been widely used in orthopedic surgery, but its efficacy in adolescent scoliosis (AS) surgery remains unclear in the literature. The purpose of this systematic review and meta-analysis is to evaluate the safety and efficacy of TXA compared to placebo treatment during or after AS surgery, by gathering data from randomized both controlled trials (RCTs) and non-RCTs.

Methods

English and Chinese electronic databases including PubMed, Web of Science, Embase, Cochrane, CNKI, and Wan Fang database were searched to identify the relevant literature up until August 2022. The primary outcomes were intraoperative blood loss and total blood loss. The secondary outcomes included the need for transfusion, postoperative hemoglobin (Hb) level, and chan

SUBMITTER: Chen K 

PROVIDER: S-EPMC10463947 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature