Dataset Information

Impact of early postoperative blood glucose variability on serum endocan level in cardiac surgery patients: a sub study of the ENDOLUNG observational study.

ABSTRACT:

Background

Early postoperative glycemic variability is associated with worse outcome after cardiac surgery, but the underlying mechanisms remain unknown. This study aimed to describe the relationship between postoperative glycemic variability and endothelial function, as assessed by serum endocan level in cardiac surgery patients.

Methods

We performed a post hoc analysis of patients included in the single-center observational ENDOLUNG study. Adult patients who underwent planned isolated coronary artery bypass graft surgery were eligible. Postoperative glycemic variability was assessed by calculating the coefficient of variability (CV) of blood glucose measured within 24 (CV₂₄) and 48 (CV₄₈) hours after surgery. Serum endocan level was measured at 24 (Endocan₂₄) and 48 (Endocan₄₈) hours after surgery. Pearson's correlation coefficient with 95% confidence interval (95% CI) was calculated between CV₂₄ and Endocan₂₄, and between CV₄₈ and Endocan₄₈.

Results

Data from 177 patients were analyzed. Median CV₂₄ and CV₄₈ were 18% (range 7 to 39%) and 20% (range 7 to 35%) respectively. Neither CV₄₈ nor CV₂₄ were significantly correlated to Endocan₄₈ and Endocan₂₄ respectively (r (95% CI) = 0.150 (0.001 to 0.290; and r (95% CI) = 0.080 (-0.070 to 0.220), respectively).

Conclusions

Early postoperative glycemic variability within 48 h after planned cardiac surgery does not appear to be correlated with postoperative serum endocan level.

Clinical trial registration number

NCT02542423.

SUBMITTER: Chazal E

PROVIDER: S-EPMC10464002 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Publications

Impact of early postoperative blood glucose variability on serum endocan level in cardiac surgery patients: a sub study of the ENDOLUNG observational study.

Chazal Etienne E Morin Lucas L Chocron Sidney S Lassalle Philippe P Pili-Floury Sebastien S Salomon du Mont Lucie L Ferreira David D Samain Emmanuel E Perrotti Andrea A Besch Guillaume G

Cardiovascular diabetology 20230824 1

<h4>Background</h4>Early postoperative glycemic variability is associated with worse outcome after cardiac surgery, but the underlying mechanisms remain unknown. This study aimed to describe the relationship between postoperative glycemic variability and endothelial function, as assessed by serum endocan level in cardiac surgery patients.<h4>Methods</h4>We performed a post hoc analysis of patients included in the single-center observational ENDOLUNG study. Adult patients who underwent planned is ...[more]

PMID: 37620974

Similar Datasets

Project description:BackgroundEndocan (EN) was suggested a potential inflammatory and cardiovascular disease (CVD) marker which might also be involved in renal failure and/or renal failure-associated vascular events. It is not clear whether osteoprotegerin (OPG) is a pro- or anti-atherogenic factor, however, it is agreed upon that OPG is elevated in subjects with increased calcification status. The aim of the study was to investigate the influence of long-term physical activity on serum endocan (EN) and osteoprotegerin-levels.MethodsOne hundred nine subjects were told to increase their amount of physical activity for 8 months by performing 150min/week moderate or 75min/week vigorous exercise. Incremental cycle ergometer tests were performed at the beginning and the end of the study to prove and quantify the performance gain. Blood samples were drawn at baseline and every 2 months for the determination of EN and OPG. To investigate the difference between baseline and 8 months levels of EN and OPG we used a paired sample t-test. To investigate the significance of the tendency of the progression (baseline/2 months/4 months/6 months/8 months) we used a Friedman test.ResultsThirty-eight female and 60 male subjects completed the study. In the group of 61 subjects who had a performance gain by >4,9% EN-levels increased from 146 ± 110 to 196 ± 238 pg/ml (p = 0,036) equivalent to an increase of 33,5% but there was no significant change in OPG (4,4 ± 2,4 pmol/l vs. 4,3 ± 2,1 pmol/l; p = 0,668).ConclusionsPhysical activity increases significantly EN-levels relativizing the status of EN as proinflammatory factor. EN should rather be considered as a mediator which is involved in several physiological (e.g., angiogenesis) but also pathological processes (e.g., CVD, tumour progression or endothelium-dependent inflammation) and whose expression can be significantly influenced by long term endurance training.Trial registrationClinical trial registration number: NCT02097199 Date of trial registration at Clinical Trials.gov: 24.03.2014; last update: 6.1.2016.

Dataset Information

Impact of early postoperative blood glucose variability on serum endocan level in cardiac surgery patients: a sub study of the ENDOLUNG observational study.

Background

Methods

Results

Conclusions

Clinical trial registration number

Publications

Impact of early postoperative blood glucose variability on serum endocan level in cardiac surgery patients: a sub study of the ENDOLUNG observational study.

Similar Datasets

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