Multi-omics reveal microbial determinants impacting the treatment outcome of antidepressants in major depressive disorder.

ABSTRACT:

Background

There is a growing body of evidence suggesting that disturbance of the gut-brain axis may be one of the potential causes of major depressive disorder (MDD). However, the effects of antidepressants on the gut microbiota, and the role of gut microbiota in influencing antidepressant efficacy are still not fully understood.

Results

To address this knowledge gap, a multi-omics study was undertaken involving 110 MDD patients treated with escitalopram (ESC) for a period of 12 weeks. This study was conducted within a cohort and compared to a reference group of 166 healthy individuals. It was found that ESC ameliorated abnormal blood metabolism by upregulating MDD-depleted amino acids and downregulating MDD-enriched fatty acids. On the other hand, the use of ESC showed a r

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10464022 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature