Identification of immune-related lncRNA in sepsis by construction of ceRNA network and integrating bioinformatic analysis.

ABSTRACT:

Background

Sepsis is a high mortality disease which seriously threatens human life and health, for which the pathogenetic mechanism still unclear. There is increasing evidence showed that immune and inflammation responses are key players in the development of sepsis pathology. LncRNAs, which act as ceRNAs, have critical roles in various diseases. However, the regulatory roles of ceRNA in the immunopathogenesis of sepsis have not yet been elucidated.

Results

In this study, we aimed to identify immune biomarkers associated with sepsis. We first generated a global immune-associated ceRNA (IMCE) network based on data describing interactions pairs of gene-miRNA and miRNA-lncRNA. Afterward, we excavated a dysregulated sepsis immune-associated ceRNA (SPIMC) network from the global

SUBMITTER: Wang T 

PROVIDER: S-EPMC10464037 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature