Changes in brain functional networks in remitted major depressive disorder: a six-month follow-up study.

ABSTRACT:

Background

Patients with remitted major depressive disorder (rMDD) show abnormal functional connectivity of the central executive network (CEN), salience networks (SN) and default mode network (DMN). It is unclear how these change during remission, or whether changes are related to function.

Methods

Three spatial networks in 17 patients with rMDD were compared between baseline and the six-month follow-up, and to 22 healthy controls. Correlations between these changes and psychosocial functioning were also assessed.

Results

In the CEN, patients at baseline had abnormal functional connectivity in the right anterior cingulate, right dorsolateral prefrontal cortex (DLPFC) and inferior parietal lobule (IPL) compare with HCs. There were functional connection differences in

SUBMITTER: Zhong J 

PROVIDER: S-EPMC10464087 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature