Dataset Information
Changes in brain functional networks in remitted major depressive disorder: a six-month follow-up study.
Ontology highlight
ABSTRACT: Background
Patients with remitted major depressive disorder (rMDD) show abnormal functional connectivity of the central executive network (CEN), salience networks (SN) and default mode network (DMN). It is unclear how these change during remission, or whether changes are related to function.Methods
Three spatial networks in 17 patients with rMDD were compared between baseline and the six-month follow-up, and to 22 healthy controls. Correlations between these changes and psychosocial functioning were also assessed.Results
In the CEN, patients at baseline had abnormal functional connectivity in the right anterior cingulate, right dorsolateral prefrontal cortex (DLPFC) and inferior parietal lobule (IPL) compare with HCs. There were functional connection differences in the right DLPFC and left IPL at baseline during follow-up. Abnormal connectivity in the right DLPFC and medial prefrontal cortex (mPFC) were found at follow-up. In the SN, patients at baseline had abnormal functional connectivity in the insula, left anterior cingulate, left IPL, and right precuneus; compared with baseline, patients had higher connectivity in the right DLPFC at follow-up. In the DMN, patients at baseline had abnormal functional connectivity in the right mPFC. Resting-state functional connectivity of the IPL and DLPFC in the CEN correlated with psychosocial functioning.Conclusions
At six-month follow-up, the CEN still showed abnormal functional connectivity in those with rMDD, while anomalies in the SN and DMN has disappeared. Resting-state functional connectivity of the CEN during early rMDD is associated with psychosocial function.Clinical trials registration
Pharmacotherapy and Psychotherapy for MDD after Remission on Psychology and Neuroimaging. https://www.Clinicaltrials
gov/ , registration number: NCT01831440 (15/4/2013).
SUBMITTER: Zhong J
PROVIDER: S-EPMC10464087 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Publications
Changes in brain functional networks in remitted major depressive disorder: a six-month follow-up study.
BMC psychiatry 20230828 1
<h4>Background</h4>Patients with remitted major depressive disorder (rMDD) show abnormal functional connectivity of the central executive network (CEN), salience networks (SN) and default mode network (DMN). It is unclear how these change during remission, or whether changes are related to function.<h4>Methods</h4>Three spatial networks in 17 patients with rMDD were compared between baseline and the six-month follow-up, and to 22 healthy controls. Correlations between these changes and psychosoc ...[more]