Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns.

ABSTRACT:

Background

Health outcomes among children born prematurely are known to be sexually dimorphic, with male infants often more affected, yet the mechanism behind this observation is not clear. CpG methylation levels in the placenta and blood also differ by sex and are associated with adverse health outcomes. We contrasted CpG methylation levels in the placenta and neonatal blood (n = 358) from the Extremely Low Gestational Age Newborn (ELGAN) cohort based on the EPIC array, which assays over 850,000 CpG sites across the epigenome. Sex-specific epigenome-wide association analyses were conducted for the placenta and neonatal blood samples independently, and the results were compared to determine tissue-specific differences between the methylation patterns in males and females. All model

SUBMITTER: Santos HP 

PROVIDER: S-EPMC10464100 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature