Various arrangements of mobile genetic elements among CC147 subpopulations of Klebsiella pneumoniae harboring bla_NDM-1: a comparative genomic analysis of carbapenem resistant strains.

ABSTRACT:

Background

Certain clonal complexes (CCs) of Klebsiella pneumoniae such as CC147 (ST147 and ST392) are major drivers of bla_NDM dissemination across the world. ST147 has repeatedly reported from our geographical region, but its population dynamics and evolutionary trajectories need to be further studied.

Methods

Comparative genomic analysis of 51 carbapenem-nonsusceptible strains as well as three hypervirulent K. pneumoniae (hvKp) recovered during 16-months of surveillance was performed using various bioinformatics tools. We investigated the genetic proximity of our ST147 strains with publicly available corresponding genomes deposited globally and from neighbor countries in our geographic region.

Results

While IncL/M plasmid harboring bla_OXA-48 wa

SUBMITTER: Pajand O 

PROVIDER: S-EPMC10464136 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature