Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor.

ABSTRACT: Human immunodeficiency virus (HIV) and other lentiviruses adapt to new hosts by evolving to evade host-specific innate immune proteins that differ in sequence and often viral recognition between host species. Understanding how these host antiviral proteins, called restriction factors, constrain lentivirus replication and transmission is key to understanding the emergence of pandemic viruses like HIV-1. Human TRIM34, a paralogue of the well-characterized lentiviral restriction factor TRIM5α, was previously identified by our lab via CRISPR-Cas9 screening as a restriction factor of certain HIV and SIV capsids. Here, we show that diverse primate TRIM34 orthologues from non-human primates can restrict a range of Simian Immunodeficiency Virus (SIV) capsids including SIV_AGM-SAB, SIV

SUBMITTER: Twentyman J 

PROVIDER: S-EPMC10464172 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature