Dose-related immunomodulatory effects of recombinant TRAIL in the tumor immune microenvironment.

ABSTRACT:

Background

In addition to specifically inducing tumor cell apoptosis, recombinant tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has also been reported to influence the cancer immune microenvironment; however, its underlying effects and mechanisms remain unclear. Investigating the immunomodulatory effects and mechanisms of recombinant TRAIL in the tumor microenvironment (TME) may provide an important perspective and facilitate the exploration of novel TRAIL strategies for tumor therapy.

Methods

Immunocompetent mice with different tumors were treated with three doses of recombinant TRAIL, and then the tumors were collected for immunological detection and mechanistic investigation. Methodological approaches include flow cytometry analysis and single-cell

SUBMITTER: Wang X 

PROVIDER: S-EPMC10464183 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature