Objective and subjective measures of sleep initiation are differentially associated with DNA methylation in adolescents.

ABSTRACT:

Introduction

The onset of puberty is associated with a shift in the circadian timing of sleep, leading to delayed sleep initiation [i.e., later sleep onset time (SOT)] due to later bedtimes and/or longer sleep onset latency (SOL). Several genome-wide association studies (GWAS) have identified genes that may be involved in the etiology of sleep phenotypes. However, circadian rhythms are also epigenetically regulated; therefore, epigenetic biomarkers may provide insight into the physiology of the pubertal sleep onset shift and the pathophysiology of prolonged or delayed sleep initiation.

Results

The gene-wide analysis indicated differential methylation within or around 1818 unique genes across the sleep initiation measurements using self-report, actigraphy (ACT), and polysomno

SUBMITTER: Larsen M 

PROVIDER: S-EPMC10464279 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature