A link between mitochondrial damage and the immune microenvironment of delayed onset muscle soreness.

ABSTRACT:

Background

Delayed onset muscle soreness (DOMS) is a self-healing muscle pain disorder. Inflammatory pain is the main feature of DOMS. More and more researchers have realized that changes in mitochondrial morphology are related to pain. However, the role of mitochondria in the pathogenesis of DOMS and the abnormal immune microenvironment is still unknown.

Methods

Mitochondria-related genes and gene expression data were obtained from MitoCarta3.0 and NCBI GEO databases. The network of mitochondrial function and the immune microenvironment of DOMS was constructed by computer algorithm. Subsequently, the skeletal muscle of DOMS rats was subjected to qPCR to verify the bioinformatics results. DOMS and non-DOMS histological samples were further studied by staining and transmissio

SUBMITTER: Li Z 

PROVIDER: S-EPMC10464284 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature