Multi-omics analysis of fecal samples in colorectal cancer Egyptians patients: a pilot study.

ABSTRACT:

Background

Colorectal cancer (CRC) is a public health concern and the second most common disease worldwide. This is due to genetic coding and is influenced by environmental aspects, in which the gut microbiota plays a significant role. The purpose of this study was to compare the microbiota makeup of CRC patients with that of healthy control and to identify upregulated and downregulated proteins and metabolites in CRC patients. Using a next-generation sequencing approach, fecal samples of five females (4 CRC patients and one healthy control) were analyzed by BGI DNBSEQ-T7, Hong Kong, China. Furthermore, proteomics and metabolomics analysis were performed using LC-MS/MS technique.

Results

Dysbiosis of gut microbiota has been observed in patients with CRC, with an increase in

SUBMITTER: Khattab RH 

PROVIDER: S-EPMC10464353 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature