Adverse associations between maternal deoxynivalenol exposure and birth outcomes: a prospective cohort study in China.

ABSTRACT:

Background

Deoxynivalenol (DON), one of the most prevalent mycotoxins, has been found to cause fetal growth retardation in animals. However, limited evidence exists regarding its effects on pregnant women.

Methods

Maternal urinary concentration of total DON (tDON) and free DON (fDON) in the second trimester was measured using liquid chromatography with tandem mass spectrometry. Provisional daily intake (PDI) of DON was calculated based on tDON concentration. Linear and logistic regression models were used to evaluate the association between DON exposure levels and birth weight, birth length, and the risk of small for gestational age (SGA).

Results

Among 1538 subjects, the median concentrations of tDON and fDON were 12.1 ng/mL and 5.1 ng/mL, respectively. The PDI value

SUBMITTER: Tan T 

PROVIDER: S-EPMC10464359 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature