Cell-free fat extract restores hair loss: a novel therapeutic strategy for androgenetic alopecia.

ABSTRACT:

Background

Androgenetic alopecia (AGA) is one of the most common hair loss diseases worldwide. However, current treatments including medicine, surgery, and stem cells are limited for various reasons. Cell-free fat extract (CEFFE), contains various cell factors, may have potential abilities in treating AGA. This study aims to evaluate the safety, effectiveness and the underlying mechanism of CEFFE in treating AGA.

Methods

Sex hormone evaluation, immunogenicity assay and genotoxicity assay were conducted for CEFFE. In vivo study, male C57BL/6 mice were injected subcutaneously with dihydrotestosterone (DHT) and were treated with different concentration of CEFFE for 18 days (five groups and n = 12 in each group: Control, Model, CEFFE^Low, CEFFE^Middle, CEFFE<

SUBMITTER: Cai Y 

PROVIDER: S-EPMC10464375 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature