A study on the chemical stability of cholesterol-lowering drugs in concomitant simple suspensions with magnesium oxide.

ABSTRACT:

Background

Difficulty in taking solid medicines is a common issue particularly for the elderly because of a decline in swallowing function, also known as dysphagia. For patients with such a dysfunction, a simple suspension method, in which solid medicines are disintegrated and suspended using warm water, has been developed and widely used in Japanese clinical settings. However, there is little information on drug stability in the simple co-suspension of multiple formulations especially including acidic or alkaline ones. In this study, the chemical stability of typical cholesterol-lowering drugs was investigated in a simple co-suspension with alkaline magnesium oxide (MgO) which is frequently used as a laxative or antacid in Japan.

Methods

A cholesterol-lowering drug (one tab

SUBMITTER: Kato G 

PROVIDER: S-EPMC10464426 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature