Neuroprotective effect of nose-to-brain delivery of Asiatic acid in solid lipid nanoparticles and its mechanisms against memory dysfunction induced by Amyloid Beta_1-42 in mice.

ABSTRACT:

Background

Amyloid-β_1-42 (Aβ_1-42) plays an essential role in the development of the early stage of Alzheimer's disease (AD). Asiatic acid (AA), an active compound in Centella asiatica L, exhibit neuroprotective properties in previous studies. Due to its low bioavailability, the nose-to-brain delivery technique was used to enhance AA penetration in the brain. In this study, AA was also loaded in solid lipid nanoparticles (SLNs) as a strategy to increase its absorption in the nasal cavity.

Methods

Memory impairment was induced via direct intracerebroventricular injection of Aβ_1-42 oligomer into mouse brain. The neuroprotective effect and potential underlying mechanisms were investigated using several memory behavioral examinations and molecular

SUBMITTER: Islamie R 

PROVIDER: S-EPMC10464452 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature