Repeated closed-head mild traumatic brain injury-induced inflammation is associated with nociceptive sensitization.

ABSTRACT:

Background

Individuals who have experienced mild traumatic brain injuries (mTBIs) suffer from several comorbidities, including chronic pain. Despite extensive studies investigating the underlying mechanisms of mTBI-associated chronic pain, the role of inflammation in long-term pain after mTBIs is not fully elucidated. Given the shifting dynamics of inflammation, it is important to understand the spatial-longitudinal changes in inflammatory processes following mTBIs and their effects on TBI-related pain.

Methods

We utilized a recently developed transgenic caspase-1 luciferase reporter mouse model to monitor caspase-1 activation through a thinned skull window in the in vivo setting following three closed-head mTBI events. Organotypic coronal brain slice cultures and acutely di

SUBMITTER: Nguyen T 

PROVIDER: S-EPMC10464478 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature