Gut microbiome causal impacts on the prognosis of breast cancer: a Mendelian randomization study.

ABSTRACT:

Background

Growing evidence has shown that gut microbiome composition is associated with breast cancer (BC), but the causality remains unknown. We aimed to investigate the link between BC prognosis and the gut microbiome at various oestrogen receptor (ER) statuses.

Methods

We performed a genome-wide association study (GWAS) to analyse the gut microbiome of BC patients, the dataset for which was collected by the Breast Cancer Association Consortium (BCAC). The analysis was executed mainly via inverse variance weighting (IVW); the Mendelian randomization (MR) results were verified by heterogeneity tests, sensitivity analysis, and pleiotropy analysis.

Results

Our findings identified nine causal relationships between the gut microbiome and total BC cases, with ten and nin

SUBMITTER: Hong W 

PROVIDER: S-EPMC10464481 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature