Efficient delivery of mesenchymal stem/stromal cells to injured liver by surface PEGylation.

ABSTRACT:

Background

Mesenchymal stem/stromal cells (MSCs) have been used in clinical trials for various diseases. These have certain notable functions such as homing to inflammation sites, tissue repair, and immune regulation. In many pre-clinical studies, MSCs administered into peripheral veins demonstrated effective therapeutic outcomes. However, most of the intravenously administered MSCs were entrapped in the lung, and homing to target sites was less than 1%. This occurred mainly because of the adhesion of MSCs to vascular endothelial cells in the lung. To prevent this adhesion, we modified the surface of MSCs with polyethylene glycol (PEG; a biocompatible polymer) using the avidin-biotin complex (ABC) method.

Methods

The surface of MSCs was modified with PEG using the ABC method

SUBMITTER: Takayama Y 

PROVIDER: S-EPMC10464485 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature