Identification and prediction model of placenta-brain axis genes associated with neurodevelopmental delay in moderate and late preterm children.

ABSTRACT:

Background

Moderate and late preterm (MLPT) birth accounts for the vast majority of preterm births, which is a global public health problem. The association between MLPT and neurobehavioral developmental delays in children and the underlying biological mechanisms need to be further revealed. The "placenta-brain axis" (PBA) provides a new perspective for gene regulation and risk prediction of neurodevelopmental delays in MLPT children.

Methods

The authors performed multivariate logistic regression models between MLPT and children's neurodevelopmental outcomes, using data from 129 MLPT infants and 3136 full-term controls from the Ma'anshan Birth Cohort (MABC). Furthermore, the authors identified the abnormally regulated PBA-related genes in MLPT placenta by bioinformatics anal

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10464496 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature