Bioinformatics analysis of potential common pathogenic mechanism for carotid atherosclerosis and Parkinson's disease.

ABSTRACT:

Background

Cerebrovascular disease (CVD) related to atherosclerosis and Parkinson's disease (PD) are two prevalent neurological disorders. They share common risk factors and frequently occur together. The aim of this study is to investigate the association between atherosclerosis and PD using genetic databases to gain a comprehensive understanding of underlying biological mechanisms.

Methods

The gene expression profiles of atherosclerosis (GSE28829 and GSE100927) and PD (GSE7621 and GSE49036) were downloaded from the Gene Expression Omnibus (GEO) database. After identifying the common differentially expressed genes (DEGs) for these two disorders, we constructed protein-protein interaction (PPI) networks and functional modules, and further identified hub genes using Least Abs

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10464527 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature