Ontology highlight
ABSTRACT:
SUBMITTER: Ahmad S
PROVIDER: S-EPMC10464598 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Ahmad Sajjad S Khan Momin M Alam Aftab A Ajmal Amar A Wadood Abdul A Khan Azim A AlAsmari Abdullah F AF Alharbi Metab M Alshammari Abdulrahman A Shakoor Abdul A
RSC advances 20230829 37
In this study, twenty eight novel oxadiazole derivatives (5-32) of the marketed available non-steroidal anti-inflammatory drug (NSAID), (<i>S</i>)-flurbiprofen (1), were synthesized <i>via</i> I<sub>2</sub> mediated cyclo-addition reaction in better yields. The synthesized hydrazone-Schiff bases were cyclized with iodine by using potassium hydroxide as a base in DMSO solvent to obtain oxadiazole derivatives (5-32). Structures of the synthesized products were confirmed with HR-ESI-MS, <sup>1</sup ...[more]