A Mechanical Assay for the Quantification of Anti-RBD IgG Levels in Finger-Prick Whole Blood.

ABSTRACT: A large portion of the global population has been vaccinated with various vaccines or infected with SARS-CoV-2, the virus that causes COVID-19. The resulting IgG antibodies that target the receptor binding domain (RBD) of SARS-CoV-2 play a vital role in reducing infection rates and severe disease outcomes. Different immune histories result in the production of anti-RBD IgG antibodies with different binding affinities to RBDs of different variants, and the levels of these antibodies decrease over time. Therefore, it is important to have a low-cost, rapid method for quantifying the levels of anti-RBD IgG in decentralized testing for large populations. In this study, we describe a 30 min assay that allows for the quantification of anti-RBD IgG levels in a single drop of finger-prick whole blo

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC10464602 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature