Large-scale template-based structural modeling of T-cell receptors with known antigen specificity reveals complementarity features.

ABSTRACT:

Introduction

T-cell receptor (TCR) recognition of foreign peptides presented by the major histocompatibility complex (MHC) initiates the adaptive immune response against pathogens. While a large number of TCR sequences specific to different antigenic peptides are known to date, the structural data describing the conformation and contacting residues for TCR-peptide-MHC complexes is relatively limited. In the present study we aim to extend and analyze the set of available structures by performing highly accurate template-based modeling of these complexes using TCR sequences with known specificity.

Methods

Identification of CDR3 sequences and their further clustering, based on available spatial structures, V- and J-genes of corresponding T-cell receptors, and epitopes, was perf

SUBMITTER: Shcherbinin DS 

PROVIDER: S-EPMC10464843 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature