Optimized monophasic pulses with equivalent electric field for rapid-rate transcranial magnetic stimulation.

ABSTRACT: Objective.Transcranial magnetic stimulation (TMS) with monophasic pulses achieves greater changes in neuronal excitability but requires higher energy and generates more coil heating than TMS with biphasic pulses, and this limits the use of monophasic pulses in rapid-rate protocols. We sought to design a stimulation waveform that retains the characteristics of monophasic TMS but significantly reduces coil heating, thereby enabling higher pulse rates and increased neuromodulation effectiveness.Approach.A two-step optimization method was developed that uses the temporal relationship between the electric field (E-field) and coil current waveforms. The model-free optimization step reduced the ohmic losses of the coil current and constrained the error of the E-field waveform compar

SUBMITTER: Wang B 

PROVIDER: S-EPMC10464893 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature