Dietary change without caloric restriction maintains a youthful profile in ageing yeast.

ABSTRACT: Caloric restriction increases lifespan and improves ageing health, but it is unknown whether these outcomes can be separated or achieved through less severe interventions. Here, we show that an unrestricted galactose diet in early life minimises change during replicative ageing in budding yeast, irrespective of diet later in life. Average mother cell division rate is comparable between glucose and galactose diets, and lifespan is shorter on galactose, but markers of senescence and the progressive dysregulation of gene expression observed on glucose are minimal on galactose, showing that these are not intrinsic aspects of replicative ageing but rather associated processes. Respiration on galactose is critical for minimising hallmarks of ageing, and forced respiration during ageing on glucos

SUBMITTER: Horkai D 

PROVIDER: S-EPMC10464975 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature