Development of a high-throughput in vitro screening method for the assessment of cell-damaging activities of snake venoms.

ABSTRACT: Snakebite envenoming is a globally important public health issue that has devastating consequences on human health and well-being, with annual mortality rates between 81,000 and 138,000. Snake venoms may cause different pathological effects by altering normal physiological processes such as nervous transfer and blood coagulation. In addition, snake venoms can cause severe (local) tissue damage that may result in life-long morbidities, with current estimates pointing towards an additional 450,000 individuals that suffer from permanent disabilities such as amputations, contractions and blindness. Despite such high morbidity rates, research to date has been mainly focusing on neurotoxic and haemotoxic effects of snake venoms and considerably less on venom-induced tissue damage. The molecular

SUBMITTER: Bittenbinder MA 

PROVIDER: S-EPMC10465002 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature