Digoxin Discontinuation and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction.

ABSTRACT:

Background

The deleterious effects of discontinuation of digoxin on outcomes in ambulatory patients with chronic heart failure (HF) with reduced ejection fraction (HFrEF) receiving angiotensin-converting enzyme inhibitors are well-documented.

Objectives

The authors sought to determine the relationship between digoxin discontinuation and outcomes in hospitalized patients with HFrEF receiving more contemporary guideline-directed medical therapies including beta-blockers and mineralocorticoid receptor antagonists.

Methods

Of the 11,900 hospitalized patients with HFrEF (EF ≤45%) in the Medicare-linked OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure) registry, 3,499 received pre-admission digoxin, which was discon

SUBMITTER: Malik A 

PROVIDER: S-EPMC10465068 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature