Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure.

ABSTRACT:

Background

Endotrophin, a collagen type VI-derived peptide, mediates metabolic dysregulation, inflammation, and fibrosis in animal models, but has not been studied in human heart failure (HF).

Methods

We examined the association between circulating endotrophin and outcomes in participants suffering from HF with preserved ejection fraction (HFpEF) enrolled in the TOPCAT trial (n=205). Associations were validated in a participant-level meta-analysis (n=810) that included participants with HFpEF from the PHFS study (United States; n=174), PEOPLE cohort (New Zealand; n=168), a randomized trial of vasodilator therapy (United States; n=45), a cohort from Donostia University Hospital and University of Navarra (Spain; n=171), and the TRAINING-HF trial (Spain; n=47). We also assessed

SUBMITTER: Chirinos JA 

PROVIDER: S-EPMC10465122 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature