Histone deacetylase-mediated tumor microenvironment characteristics and synergistic immunotherapy in gastric cancer.

ABSTRACT: Background: Studies have shown that the expression of histone deacetylases (HDACs) is significantly related to the tumor microenvironment (TME) in gastric cancer. However, the expression of a single molecule or several molecules does not accurately reflect the TME characteristics or guide immunotherapy in gastric cancer. Methods: We constructed an HDAC score (HDS) based on the expression level of HDACs. The single-cell transcriptome was used to analyze the underlying factors contributing to differences in immune infiltration between patients with a high and low HDS. In vitro and in vivo experiments validated the strategy of transforming cold tumors into hot tumors to guide immunotherapy. Results: According to the expression characteristics of HDACs, we co

SUBMITTER: Lin Y 

PROVIDER: S-EPMC10465215 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature